Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …

Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but
assessing their consistency and reproducibility across iPSC lines, and reducing the …

The availability of viral entry factors is a prerequisite for the cross-species transmission of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell …

Human complex traits and common diseases show tissue-and cell-type-specificity. Recently,
single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular …