Activation of the renin–angiotensin–aldosterone system (RAAS) results in vasoconstriction,
muscular (vascular and cardiac) hypertrophy and fibrosis. Established arterial stiffness and …

A organização de uma diretriz clínica é tarefa complexa, que necessariamente deve
envolver planejamento prévio, coordenação apropriada, revisão aprofundada da literatura …

This is the second part of a 2-part article that presents a critical and comprehensive update
of the current evidence for a cardiovascular disease (CVD) continuum based on the results …

The recommendations listed in this CPG are, whenever possible, evidence based. An
extensive evidence review was conducted through October 2012, and other selected …

A organização de uma diretriz clínica é tarefa complexa, que necessariamente deve
envolver planejamento prévio, coordenação apropriada, revisão aprofundada da literatura …

O objetivo desta Diretriz é servir de apoio e auxiliar os médicos nas decisões referentes aos
seus pacientes, elaborando orientações que podem ser úteis na prática médica. A adoção …

Background In the studies of left ventricular dysfunction (SOLVD), enalapril reduced
mortality in patients with symptomatic but not asymptomatic left ventricular systolic …

The importance of aldosterone in the pathophysiology of chronic heart failure (HF) has been
established in previous studies [1–4] and is emphasized by the findings of the RALES trial …

Background—We have previously demonstrated that ramipril reduces vascular events and
new diagnoses of diabetes when given for a 4.5-year period. However, it is not known …

Context.—Several journals have adopted the Consolidated Standards of Reporting Trials
(CONSORT) recommendations to make assessment of the quality of randomized controlled …