Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

[HTML][HTML] Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies

Z Si, X Wang, C Sun, Y Kang, J Xu, X Wang… - Biomedicine & …, 2019 - Elsevier
Adipose-derived stem cells (ASCs) are a subset of mesenchymal stem cells (MSCs) that can
be obtained easily from adipose tissues and possess many of the same regenerative …

Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications

P Li, Q Ou, S Shi, C Shao - Cellular & molecular immunology, 2023 - nature.com
Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and play
essential roles in tissue regeneration and homeostasis. MSCs can be isolated from …

Estrogens and androgens in skeletal physiology and pathophysiology

M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Resting zone of the growth plate houses a unique class of skeletal stem cells

K Mizuhashi, W Ono, Y Matsushita, N Sakagami… - Nature, 2018 - nature.com
Skeletal stem cells regulate bone growth and homeostasis by generating diverse cell types,
including chondrocytes, osteoblasts and marrow stromal cells. The emerging concept …

Stem cell therapies in clinical trials: progress and challenges

A Trounson, C McDonald - Cell stem cell, 2015 - cell.com
Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

Stemness in cancer: stem cells, cancer stem cells, and their microenvironment

PM Aponte, A Caicedo - Stem cells international, 2017 - Wiley Online Library
Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Identification and specification of the mouse skeletal stem cell

CKF Chan, EY Seo, JY Chen, D Lo, A McArdle… - Cell, 2015 - cell.com
How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage,
and stromal development from a population of highly pure, postnatal skeletal stem cells …

No identical “mesenchymal stem cells” at different times and sites: human committed progenitors of distinct origin and differentiation potential are incorporated as …

B Sacchetti, A Funari, C Remoli, G Giannicola… - Stem cell reports, 2016 - cell.com
A widely shared view reads that mesenchymal stem/stromal cells (" MSCs") are ubiquitous in
human connective tissues, can be defined by a common in vitro phenotype, share a …