Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Inflammasome sensors detect pathogen-and danger-associated molecular patterns and
promote inflammation and pyroptosis. NLRP1 was the first inflammasome sensor to be …

Background Circadian disturbance is a common nonmotor complaint in Parkinson's disease
(PD). The molecular basis underlying circadian rhythm in PD is poorly understood …

Cell division and cell death are fundamental processes governing growth and development
across the tree of life. This relationship represents an evolutionary link between cell cycle …

Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, has
increased in incidence and prevalence in recent decades. Both clinical and animal studies …

Moraxella catarrhalis is an important human respiratory pathogen and a major causative
agent of otitis media and chronic obstructive pulmonary disease. Toll‐like receptors …