It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

The regioselective functionalization of C60 remains challenging, while the enantioselective
functionalization of C60 is difficult to explore due to the need for complex chiral tethers or …

Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Chiral seven-membered ring systems such as seven-membered carbocycles and
heterocycles are widely found in natural products and pharmaceuticals. Therefore, the …

Chiral boronic esters are a class of versatile building blocks. We describe herein an
asymmetric nickel-catalyzed borylative coupling of terminal alkenes with nonactivated alkyl …

The direct functionalization of inert C (sp3)− H bonds under environmentally benign catalytic
conditions remains a challenging task in synthetic chemistry. Here, we report an …

Developing eco-friendly chiral organocatalysts with the combined advantages of
homogeneous catalysis and heterogeneous processes is greatly desired. In this work, a …

We designed bifunctional 4-pyrrolidinopyridines as powerful Lewis base catalysts. The
catalyst structure features a 4-hydroxy-2-(hydroxydiphenylmethyl) pyrrolidine-1-formyl group …