Oxidative stress in cardiovascular diseases: still a therapeutic target?

T Senoner, W Dichtl - Nutrients, 2019 - mdpi.com
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

Biomarkers of oxidative stress tethered to cardiovascular diseases

P Panda, HK Verma, S Lakkakula… - Oxidative Medicine …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) is a broad term that incorporated a group of conditions that
affect the blood vessels and the heart. CVD is a foremost cause of fatalities around the …

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

The role of mitochondrial dysfunction in vascular disease, tumorigenesis, and diabetes

OA Zhunina, NG Yabbarov, AV Grechko… - Frontiers in Molecular …, 2021 - frontiersin.org
Mitochondrial dysfunction is known to be associated with a wide range of human
pathologies, such as cancer, metabolic, and cardiovascular diseases. One of the possible …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
Atherosclerosis is a multifactorial disease of the cardiovascular system associated with
aging, inflammation, and oxidative stress. An important role in the development of …

From mitochondria to atherosclerosis: the inflammation path

JM Suárez-Rivero, CJ Pastor-Maldonado… - Biomedicines, 2021 - mdpi.com
Inflammation is a key process in metazoan organisms due to its relevance for innate defense
against infections and tissue damage. However, inflammation is also implicated in …

Lipid metabolism in macrophages: focus on atherosclerosis

VN Sukhorukov, VA Khotina, YS Chegodaev… - Biomedicines, 2020 - mdpi.com
Mechanisms of lipid homeostasis and its impairment are of crucial importance for
atherogenesis, and their understanding is necessary for successful development of new …

Novel insights and current evidence for mechanisms of atherosclerosis: mitochondrial dynamics as a potential therapeutic target

D Li, S Yang, Y Xing, L Pan, R Zhao, Y Zhao… - Frontiers in Cell and …, 2021 - frontiersin.org
Cardiovascular disease (CVD) is the main cause of death worldwide. Atherosclerosis is the
underlying pathological basis of CVD. Mitochondrial homeostasis is maintained through the …

Mitochondrial respiratory complexes: Significance in human mitochondrial disorders and cancers

KS Vikramdeo, SK Sudan, AP Singh… - Journal of Cellular …, 2022 - Wiley Online Library
Mitochondria are pivotal organelles that govern cellular energy production through the
oxidative phosphorylation system utilizing five respiratory complexes. In addition …

The molecular biomarkers of vascular aging and atherosclerosis: Telomere length and mitochondrial DNA4977 common deletion

C Vecoli, A Borghini, MG Andreassi - Mutation Research/Reviews in …, 2020 - Elsevier
Age is the dominant risk factor for the most prevalent atherosclerotic vascular diseases,
including coronary artery disease, myocardial infarction, cerebrovascular disease and …