Detection of alternative DNA structures and its implications for human disease

G Matos-Rodrigues, JA Hisey, A Nussenzweig… - Molecular Cell, 2023 - cell.com
Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

Template-assembled synthetic G-quartets (TASQs): multiTASQing molecular tools for investigating DNA and RNA G-quadruplex biology

D Monchaud - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …

Organometallic pillarplexes that bind DNA 4-way Holliday junctions and forks

JS Craig, L Melidis, HD Williams… - Journal of the …, 2023 - ACS Publications
Holliday 4-way junctions are key to important biological DNA processes (insertion,
recombination, and repair) and are dynamic structures that adopt either open or closed …

DNA-based molecular recognition system for lactoferrin biosensing

A Paziewska-Nowak, M Urbanowicz… - International Journal of …, 2023 - Elsevier
The paper describes the development of a novel DNA oligonucleotide-based affinity
bioreceptor that binds to lactoferrin, a glycoprotein-type immunomodulator. The research …

Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation

A Pruška, JA Harrison, A Granzhan… - Analytical …, 2023 - ACS Publications
DNA three-way junction (TWJ) structures transiently form during key cellular processes such
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …

Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

J Malina, H Kostrhunova, P Scott… - Nucleic Acids …, 2023 - academic.oup.com
DNA three-way junctions (3WJ) represent one of the simplest supramolecular DNA
structures arising as intermediates in homologous recombination in the absence of …

G-quadruplex-mediated genomic instability drives SNVs in cancer

T Richl, J Kuper, C Kisker - Nucleic Acids Research, 2024 - academic.oup.com
Abstract G-quadruplex (G4s) DNA structures have been implicated in inducing genomic
instability and contributing to cancer development. However, the relationship between G4s …

i-Motif DNA: identification, formation, and cellular functions

S Tao, Y Run, D Monchaud, W Zhang - Trends in Genetics, 2024 - Elsevier
An i-motif (iM) is a four-stranded (quadruplex) DNA structure that folds from cytosine (C)-rich
sequences. iMs can fold under many different conditions in vitro, which paves the way for …

[HTML][HTML] Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects

SC Huang, CW Chen, R Satange… - Nucleic Acids …, 2024 - academic.oup.com
Targeting inter-duplex junctions in catenated DNA with bidirectional bis-intercalators is a
potential strategy for enhancing anticancer effects. In this study, we used d (CGTATACG) 2 …

Structural Optimization of Azacryptands for Targeting Three‐Way DNA Junctions

A Pipier, T Chetot, A Kalamatianou… - Angewandte Chemie …, 2024 - Wiley Online Library
Transient melting of the duplex‐DNA (B‐DNA) during DNA transactions allows repeated
sequences to fold into non‐B DNA structures, including DNA junctions and G‐quadruplexes …