The neurobiology of SARS-CoV-2 infection

J Meinhardt, S Streit, C Dittmayer, RV Manitius… - Nature Reviews …, 2024 - nature.com
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

Systems analysis of innate and adaptive immunity in Long COVID

MJ Peluso, M Abdel-Mohsen, TJ Henrich… - Seminars in …, 2024 - Elsevier
Since the onset of the COVID-19 pandemic, significant progress has been made in
developing effective preventive and therapeutic strategies against severe acute SARS-CoV …

Vortioxetine for the treatment of post-COVID-19 condition: a randomized controlled trial

RS McIntyre, L Phan, ATH Kwan, RB Mansur… - Brain, 2024 - academic.oup.com
Hitherto no therapeutic has received regulatory approval for the treatment of post-COVID-19
condition (PCC). Cognitive deficits, mood symptoms and significant reduction in health …

[HTML][HTML] Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a …

DL Wannigama, C Hurst, P Phattharapornjaroen… - …, 2024 - thelancet.com
Background Repurposed drugs with host-directed antiviral and immunomodulatory
properties have shown promise in the treatment of COVID-19, but few trials have studied …

[HTML][HTML] Long Covid and Impaired Cognition—More Evidence and More Work to Do

Z Al-Aly, CJ Rosen - New England Journal of Medicine, 2024 - Mass Medical Soc
During the early stages of the Covid-19 pandemic, reports emerged that persons who had
been infected with SARS-CoV-2 were having lingering health problems. Such long-term …

The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China

W Zuo, D He, C Liang, S Du, Z Hua, Q Nie… - The Lancet Infectious …, 2024 - thelancet.com
Background Growing evidence suggests that symptoms associated with post-COVID-19
condition (also known as long COVID) can affect multiple organs and systems in the human …

Long COVID's Impact on Patients, Workers, & Society: A review

KT Kavanagh, LE Cormier, C Pontus, A Bergman… - Medicine, 2024 - journals.lww.com
The incidence of long COVID in adult survivors of an acute SARS-CoV-2 infection is
approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. The …

Do the therapeutic effects of psilocybin involve actions in the gut?

F Reed, CJ Foldi - Trends in Pharmacological Sciences, 2024 - cell.com
The psychedelic compound psilocybin has recently emerged as a therapeutic intervention
for various mental health conditions. Psilocybin is a potent agonist of serotonin (5-HT) …

Solving the puzzle of Long Covid

Z Al-Aly, E Topol - Science, 2024 - science.org
More than 4 years into the global COVID-19 pandemic, widespread infection with severe
acute respiratory syndrome coronavirus 2 (SARSCoV-2) has left millions of people around …

Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract

O Kocabiyik, P Amlashi, AL Vo, H Suh… - Science …, 2024 - science.org
Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal tract, but
traditional vaccination strategies typically elicit little or no mucosal antibody responses …