[HTML][HTML] MMP-9/BDNF ratio predicts more severe COVID-19 outcomes
G Savic, I Stevanovic, D Mihajlovic… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
COVID-19 clinically manifests from asymptomatic to the critical range. Immune response
provokes the pro-inflammatory interactions, which lead to the cytokines, reactive …
provokes the pro-inflammatory interactions, which lead to the cytokines, reactive …
[HTML][HTML] siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury
IV Chernikov, YY Staroseletz, IS Tatarnikova… - International Journal of …, 2023 - mdpi.com
Acute lung injury is a complex cascade process that develops in response to various
damaging factors, which can lead to acute respiratory distress syndrome. Within this study …
damaging factors, which can lead to acute respiratory distress syndrome. Within this study …
[HTML][HTML] Protective effect of soloxolone derivatives in carrageenan-and LPS-driven acute inflammation: Pharmacological profiling and their effects on key inflammation …
AV Sen'kova, IA Savin, KV Odarenko… - Biomedicine & …, 2023 - Elsevier
The anti-inflammatory potential of three cyanoenone-containing triterpenoids, including
soloxolone methyl (SM), soloxolone (S) and its novel derivative bearing at the C-30 …
soloxolone methyl (SM), soloxolone (S) and its novel derivative bearing at the C-30 …
[HTML][HTML] Identification of phytochemical compounds of Fagopyrum dibotrys and their targets by metabolomics, network pharmacology and molecular docking studies
M Zhang, X Zhang, J Pei, B Guo, G Zhang, M Li… - Heliyon, 2023 - cell.com
Acute lung injury (ALI) is a clinically severe lung illness with high incidence rate and
mortality. Especially, coronavirus disease 2019 (COVID-19) poses a serious threat to world …
mortality. Especially, coronavirus disease 2019 (COVID-19) poses a serious threat to world …
[HTML][HTML] Single-cell RNA sequencing reveals hub genes of myocardial infarction-associated endothelial cells
H Wang, L Dou - BMC Cardiovascular Disorders, 2024 - Springer
Background Myocardial infarction (MI) is a cardiovascular disease that seriously threatens
human health. Dysangiogenesis of endothelial cells (ECs) primarily inhibits recovery from …
human health. Dysangiogenesis of endothelial cells (ECs) primarily inhibits recovery from …
[HTML][HTML] Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment
WT Hu, M Kaluzova, A Dawson, V Sotelo, J Papas… - Cell Reports …, 2024 - cell.com
Natural history and mechanisms for persistent cognitive symptoms (" brain fog") following
acute and often mild COVID-19 are unknown. In a large prospective cohort of people who …
acute and often mild COVID-19 are unknown. In a large prospective cohort of people who …
[HTML][HTML] Novel epoxides of soloxolone methyl: An effect of the formation of oxirane ring and stereoisomerism on cytotoxic profile, anti-metastatic and anti-inflammatory …
OV Salomatina, AV Sen'kova, AD Moralev… - International Journal of …, 2022 - mdpi.com
It is known that epoxide-bearing compounds display pronounced pharmacological activities,
and the epoxidation of natural metabolites can be a promising strategy to improve their …
and the epoxidation of natural metabolites can be a promising strategy to improve their …
[HTML][HTML] Immune-related protein interaction network in severe COVID-19 patients toward the identification of key proteins and drug repurposing
P Sagulkoo, A Suratanee, K Plaimas - Biomolecules, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is still an active global public health issue. Although
vaccines and therapeutic options are available, some patients experience severe conditions …
vaccines and therapeutic options are available, some patients experience severe conditions …
Classification and severity progression measure of COVID-19 patients using pairs of multi-omic factors
Early detection and effective treatment of severe COVID-19 patients remain two major
challenges during the current pandemic. Analysis of molecular changes in blood samples of …
challenges during the current pandemic. Analysis of molecular changes in blood samples of …