Purpose Drug delivery to the anterior eye has a low compliance and results in significant
drug losses. In pediatric patients, eye diseases such as myopia and retinoblastoma can …

Background: Despite the disease relevance, understanding of human retinal development
lags behind that of other species. We compared the kinetics of gene silencing or induction …

Daunorubicin (DAUN) has served as an anticancer drug in chemotherapy regimens for
decades and is still irreplaceable in treatment of acute leukemias. The therapeutic outcome …

Retinoblastoma is a pediatric cancer that has served as a paradigm for tumor suppressor
gene function. Retinoblastoma is initiated by RB gene mutations, but the subsequent …

For reprint orders, please contact reprints@ future-science. com and PRC1 to the cleavage
furrow during mitosis. Both citron kinase and PRC1 are essential proteins for cytokinesis …

Germline RB1 mutations strongly predispose humans to cone precursor–derived
retinoblastomas and strongly predispose mice to pituitary tumors, yet shared cell type …

Aims/hypothesis Diabetes mellitus is characterised by beta cell loss and alpha cell
expansion. Analogues of glucagon-like peptide-1 (GLP-1) are used therapeutically to …

Retinoblastoma tumor suppressor (Rb) promotes cell cycle exit, survival, differentiation, and
tumor suppression in the retina. Here, we show it is also essential for vascularization and …

Background: Vascular endothelial growth factor (VEGF) plays an important role in the
pathogenesis of cancer. Although numerous studies have investigated the association …

The retinoblastoma tumor susceptibility gene, Rb1, is a key regulator of the cell cycle, and
mutations in this gene have been found in many human cancers. Prior studies showed that …