Considering innate immune responses in SARS-CoV-2 infection and COVID-19

MS Diamond, JD Lambris, JP Ting… - Nature Reviews …, 2022 - nature.com
During the COVID-19 pandemic, much of the media focus has been on adaptive immunity,
particularly antibody levels and memory T cells. However, immunologists have been striving …

Evolution of Sequence and Structure of SARS-CoV-2 Spike Protein: A Dynamic Perspective

A Sinha, S Sangeet, S Roy - ACS omega, 2023 - ACS Publications
Novel coronavirus (SARS-CoV-2) enters its host cell through a surface spike protein. The
viral spike protein has undergone several modifications/mutations at the genomic level …

Modelling of the innate and adaptive immune response to SARS viral infection, cytokine storm and vaccination

C Leon, A Tokarev, A Bouchnita, V Volpert - Vaccines, 2023 - mdpi.com
In this work, we develop mathematical models of the immune response to respiratory viral
infection, taking into account some particular properties of the SARS-CoV infections …

High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response

SS Burkart, D Schweinoch, J Frankish… - Life Science …, 2023 - life-science-alliance.org
RIG-I recognizes viral dsRNA and activates a cell-autonomous antiviral response. Upon
stimulation, it triggers a signaling cascade leading to the production of type I and III IFNs …

Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients

Z Zhou, D Li, Z Zhao, S Shi, J Wu, J Li… - PLOS Computational …, 2023 - journals.plos.org
Once challenged by the SARS-CoV-2 virus, the human host immune system triggers a
dynamic process against infection. We constructed a mathematical model to describe host …

Multicompartmental mathematical model of SARS-CoV-2 distribution in human organs and their treatment

VN Afonyushkin, IR Akberdin, YN Kozlova, IA Schukin… - Mathematics, 2022 - mdpi.com
Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory
distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this …

[HTML][HTML] Dynamics of a stochastic hepatitis B virus transmission model with media coverage and a case study of China

J Ma, S Ma - Mathematical Biosciences and Engineering, 2023 - aimspress.com
Hepatitis B virus (HBV) infection is a global public health problem and there are $257$
million people living with chronic HBV infection throughout the world. In this paper, we …

[HTML][HTML] The role of Type I interferons in the pathogenesis of foot-and-mouth disease virus in cattle: a mathematical modelling analysis

K Giorgakoudi, D Schley, N Juleff, S Gubbins… - Mathematical …, 2023 - Elsevier
Type I interferons (IFN) are the first line of immune response against infection. In this study,
we explore the interaction between Type I IFN and foot-and-mouth disease virus (FMDV) …

High resolution kinetic characterization and dynamic mathematical modeling of the RIG-I signaling pathway and the antiviral responses

SS Burkart, D Schweinoch, J Frankish, C Sparn, S Wüst… - bioRxiv, 2022 - biorxiv.org
The pattern recognition receptor RIG-I is essential for the recognition of viral dsRNA and the
activation of a cell-autonomous antiviral response. Upon stimulation, RIG-I triggers a …

[HTML][HTML] Macrophage Boolean networks in the time of SARS-CoV-2

UAP de León, O Resendis-Antonio - Frontiers in immunology, 2022 - frontiersin.org
The post-pandemic period of the current coronavirus disease (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lasted longer than expected …