Research progress and applications of genome‐wide association study in farm animals

X Tan, Z He, AG Fahey, G Zhao, R Liu… - Animal Research and …, 2023 - Wiley Online Library
Exploring the genetic loci underlying economic traits is foundational for innovation in
modern animal breeding technology. Genome‐wide association studies (GWAS) have been …

Recent advances in the genomic resources for sheep

SA Woolley, M Salavati, EL Clark - Mammalian Genome, 2023 - Springer
Sheep (Ovis aries) provide a vital source of protein and fibre to human populations. In
coming decades, as the pressures associated with rapidly changing climates increase …

Large-scale multiplexing permits full-length transcriptome annotation of 32 bovine tissues from a single nanopore flow cell

MM Halstead, A Islas-Trejo, DE Goszczynski… - Frontiers in …, 2021 - frontiersin.org
A comprehensive annotation of transcript isoforms in domesticated species is lacking.
Especially considering that transcriptome complexity and splicing patterns are not well …

Knocking down ETS Proto-oncogene 1 (ETS1) alleviates the pyroptosis of renal tubular epithelial cells in patients with acute kidney injury by regulating the NLR family …

C Juan, Y Zhu, Y Chen, Y Mao, Y Zhou, W Zhu… - …, 2022 - Taylor & Francis
Acute kidney injury (AKI) has a high mortality rate, but its pathogenesis remains unclear
Lipopolysaccharide (LPS)-mediated renal tubular epithelial pyroptosis is involved in the …

Cross-Species Comparative DNA Methylation Reveals Novel Insights into Complex Trait Genetics among Cattle, Sheep, and Goats

S Chen, S Liu, S Shi, H Yin, Y Tang… - Molecular Biology …, 2024 - academic.oup.com
The cross-species characterization of evolutionary changes in the functional genome can
facilitate the translation of genetic findings across species and the interpretation of the …

Enhanced bovine genome annotation through integration of transcriptomics and epi-transcriptomics datasets facilitates genomic biology

H Beiki, BM Murdoch, CA Park, C Kern… - …, 2024 - academic.oup.com
Background The accurate identification of the functional elements in the bovine genome is a
fundamental requirement for high-quality analysis of data informing both genome biology …

Improving the annotation of the cattle genome by annotating transcription start sites in a diverse set of tissues and populations using Cap Analysis Gene Expression …

M Salavati, R Clark, D Becker, C Kühn… - G3: Genes …, 2023 - academic.oup.com
Understanding the genomic control of tissue-specific gene expression and regulation can
help to inform the application of genomic technologies in farm animal breeding programs …

Research Progress and Applications of Bovine Genome in the Tribe Bovini

X Du, Y Sun, T Fu, T Gao, T Zhang - Genes, 2024 - mdpi.com
Various bovine species have been domesticated and bred for thousands of years, and they
provide adequate animal-derived products, including meat, milk, and leather, to meet human …

Evolution of tissue and developmental specificity of transcription start sites in Bos taurus indicus

M Forutan, E Ross, AJ Chamberlain, L Nguyen… - Communications …, 2021 - nature.com
To further the understanding of the evolution of transcriptional regulation, we profiled
genome-wide transcriptional start sites (TSSs) in two sub-species, Bos taurus taurus and …

Functional genomics of cattle through integration of multi-omics data

H Beiki, BM Murdoch, CA Park, C Kern, D Kontechy… - BioRxiv, 2022 - biorxiv.org
Functional annotation of the bovine genome was performed by characterizing the spectrum
of RNA transcription using a multi-omics approach, combining long-and short-read transcript …