Our forefathers in pathology, on observing cancer tissue under the microscope in the mid-
19th century, noticed the similarity between embryonic tissue and cancer, and suggested …

Highlights•Fatty acid binding protein 5 (FABP5) is a key regulator of cell metabolism and
growth that is overexpressed in cancers.•FABP5 facilitates the activation of transcriptional …

Transcriptional activation of the nuclear receptor RAR by retinoic acid (RA) often leads to
inhibition of cell growth. However, in some tissues, RA promotes cell survival and …

Many biological activities of all-trans-retinoic acid (RA) are mediated by the ligand-activated
transcription factors termed retinoic acid receptors (RARs), but this hormone can also …

Retinoic acid (RA) protects mice from diet-induced obesity. The activity is mediated in part
through activation of the nuclear receptors RA receptors (RARs) and peroxisome proliferator …

Primary sequences of proteins often contain motifs that serve as" signatures" for subcellular
targeting, such as a nuclear localization signal (NLS). However, many nuclear proteins do …

The vitamin A metabolite all-trans-retinoic acid (RA) regulates multiple biological processes
by virtue of its ability to regulate gene expression. It thus plays critical roles in embryonic …

Retinoic acid (RA) displays potent anticarcinogenic activities that are mediated by the
nuclear retinoic acid receptors (RARs). However, use of RA in oncology is limited by RA …

The transmembrane protein, STRA6, functions as a vitamin A transporter and a cytokine
receptor when activated by vitamin A-bound serum retinol binding protein 4 (RBP4). STRA6 …

Long chain fatty acids (LCFA) serve as energy sources, components of cell membranes and
precursors for signalling molecules. Here we show that these biological compounds also …