Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

Agent-based modeling (ABM) is a novel computational methodology for representing the
behavior of individuals in order to study social phenomena. Its use is rapidly growing in …

Drug resistance significantly limits the long-term effectiveness of targeted therapeutics for
cancer patients. Recent experimental studies have demonstrated that cancer cell …

Diverse forms of resistance to anticancer drugs can lead to the failure of chemotherapy.
Drug resistance is one of the most intractable issues for successfully treating cancer in …

Towards clinical translation of cancer nanomedicine, it is important to systematically
investigate the various parameters related to nanoparticle (NP) physicochemical properties …

BACKGROUND Due to difficulty in accessing relevant tissues or biological fluids to measure
drug levels, plasma drug concentrations are often collected with the hope that they will …

The energy domain is still dominated by equilibrium models that underestimate both the
dangers and opportunities related to climate change. In reality, climate and energy systems …

Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of developing personalized treatment strategies based on individual patient …

The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …