Drug resistance (DR) is a phenomenon characterized by the tolerance of a disease to
pharmaceutical treatment. In cancer patients, DR is one of the main challenges that limit the …

5-Fluorouracil (5-FU) is a standard chemotherapeutic agent to treat solid cancers such as
breast, colon, head, and neck. Computational modeling plays an essential role in predicting …

Lung cancer remains a leading cause of death. Current treatment options are generally
ineffective, highlighting the dire need for novel approaches. While numerous biologically …

Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.
It has also been demonstrated to be related to cancer heterogeneity, which promotes the …

Circulating biomarkers are of significant interest for cancer detection and treatment
personalization. However, the biophysical processes that determine how proteins are shed …

This thesis discovers mathematical modelling techniques that can be applied to the stressful
tumour microenvironment (TME) by developing an agent-based model, systems of ordinary …

An Agent-Based Model (ABM) of glioblastoma in-filtration into surrounding healthy brain
tissue is presented. The model incorporates variable cell movement rates and replication …

Simple Summary Chimeric antigen receptor (CAR) T-cell therapy has shown much promise
in liquid tumors but often fails in solid tumors. This work uses a computational model to …

In recent decades computer-aided technologies have become prevalent in medicine,
however, cancer drugs are often only tested on in vitro cell lines from biopsies. We derive a …

All aggregate biological phenomena in the aerosphere are due to the behaviors of unique
individuals acting according to their own rules of behavior and perceived external stimuli. An …