Complications of allogeneic hematopoietic stem cell transplantation

K Arnaout, N Patel, M Jain, J El-Amm, F Amro… - Cancer …, 2014 - Taylor & Francis
Infection, graft-versus-host disease (GVHD), and to a lesser extent sinusoidal obstructive
syndrome (SOS) represent the major causes of morbidity and mortality in patients …

CAMPATH: from concept to clinic

H Waldmann, G Hale - … of the Royal Society B: Biological …, 2005 - royalsocietypublishing.org
Lymphocyte depletion has a long history in the area of therapeutic immunosuppression.
CAMPATH-1H (alemtuzumab) was generated in an attempt to replace anti-lymphocyte …

Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA …

R Martino, S Iacobelli, R Brand, T Jansen… - Blood, 2006 - ashpublications.org
In this multicenter retrospective study, the outcomes of 836 patients with myelodysplastic
syndrome (MDS) who underwent transplantation with a human leukocyte antigen (HLA) …

Clinical pharmacology of alemtuzumab, an anti-CD52 immunomodulator, in multiple sclerosis

Z Li, S Richards, HK Surks, A Jacobs… - Clinical & …, 2018 - academic.oup.com
Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is approved for treatment of
relapsing multiple sclerosis (MS). In the Phase II/III trials, patients received 12 or 24 mg/day …

A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders

S Shenoy, WJ Grossman, J DiPersio, LC Yu… - Bone marrow …, 2005 - nature.com
Bone marrow transplantation (BMT) benefits nonmalignant diseases but is limited by
regimen-related toxicity, graft-versus-host disease (GVHD), donor availability, and graft …

Posttransplantation imatinib as a strategy to postpone the requirement for immunotherapy in patients undergoing reduced-intensity allografts for chronic myeloid …

E Olavarria, S Siddique, MJ Griffiths… - Blood, The Journal …, 2007 - ashpublications.org
Disease relapse is a major cause of treatment failure after reduced-intensity allografts and
while donor lymphocyte infusions (DLIs) can be effective salvage therapy they are …

Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents

AJ Barrett, BN Savani - Leukemia, 2006 - nature.com
The realization in the 1990s that allogeneic stem cell transplants (SCT) have a potentially
curative graft-versus-leukemia (GVL) effect in addition to the antileukemic action of …

Antithymocyte globulins and chronic graft-vs-host disease after myeloablative allogeneic stem cell transplantation from HLA-matched unrelated donors: a report from …

M Mohty, M Labopin, ML Balere, G Socie, N Milpied… - Leukemia, 2010 - nature.com
This retrospective report assessed the impact of rabbit antithymocyte globulins (ATG),
incorporated within a standard myeloablative conditioning regimen prior to allogeneic stem …

[HTML][HTML] Factors predicting long-term survival after T-cell depleted reduced intensity allogeneic stem cell transplantation for acute myeloid leukemia

C Craddock, S Nagra, A Peniket, C Brookes… - …, 2010 - ncbi.nlm.nih.gov
Background Reduced intensity conditioning regimens permit the delivery of a potentially
curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. Although …

[HTML][HTML] Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia

AA Kennedy-Nasser, KS Leung, A Mahajan… - Biology of Blood and …, 2006 - Elsevier
Matched sibling donor (MSD) bone marrow transplantation is the treatment of choice for
pediatric patients with severe aplastic anemia (SAA); however, only about 33% of patients …