Non-alcoholic fatty liver disease as a canonical example of metabolic inflammatory-based liver disease showing a sex-specific prevalence: relevance of estrogen …
S Della Torre - Frontiers in endocrinology, 2020 - frontiersin.org
There is extensive evidence supporting the interplay between metabolism and immune
response, that have evolved in close relationship, sharing regulatory molecules and …
response, that have evolved in close relationship, sharing regulatory molecules and …
Liver three-dimensional cellular models for high-throughput chemical testing
Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
Human liver cancer organoids: Biological applications, current challenges, and prospects in hepatoma therapy
L Chen, X Wei, D Gu, Y Xu, H Zhou - Cancer Letters, 2023 - Elsevier
Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …
Although organ transplantation, surgical resection and anticancer drugs are the main …
Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling
SK Kim, YH Kim, S Park, SW Cho - Acta biomaterialia, 2021 - Elsevier
As life expectancy improves and the number of people suffering from various diseases
increases, the need for developing effective personalized disease models is rapidly rising …
increases, the need for developing effective personalized disease models is rapidly rising …
Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
A Brooks, X Liang, Y Zhang, CX Zhao… - Pharmacological …, 2021 - Elsevier
The past decade has seen many advancements in the development of three-dimensional
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …
Three-dimensional (3D) liver cell models-a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of …
Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs)
in human health and medicine, their translation from bench to bedside is slow, with a …
in human health and medicine, their translation from bench to bedside is slow, with a …
Liver organoids: Formation strategies and biomedical applications
X Zhu, B Zhang, Y He, J Bao - Tissue Engineering and Regenerative …, 2021 - Springer
The liver is the most important digestive organ in the body. Several studies have explored
liver biology and diseases related to the liver. However, most of these studies have only …
liver biology and diseases related to the liver. However, most of these studies have only …
[HTML][HTML] Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology
In recent years, the development of 3D organoids has opened new avenues of investigation
into development, physiology, and regenerative medicine. Organoid formation and the …
into development, physiology, and regenerative medicine. Organoid formation and the …
Recent advances in chemically defined and tunable hydrogel platforms for organoid culture
Recent developments in organoid culture technologies have made it possible to closely
recapitulate intrinsic characteristics of different tissues under in vitro conditions. These …
recapitulate intrinsic characteristics of different tissues under in vitro conditions. These …
Organoid transplant approaches for the liver
Organoid technology is a state‐of‐the‐art cell culture tool that has revolutionized study of
development, regeneration, and diseases. Human liver organoids (HLOs) are now derived …
development, regeneration, and diseases. Human liver organoids (HLOs) are now derived …