The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

White blood cells (WBCs) are immune cells that play essential roles in critical diseases
including cancers, infections, and inflammatory disorders. Their dynamic and diverse …

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

BACKGROUND Neutralizing antibodies are considered a key correlate of protection by
current SARS-CoV-2 vaccines. The manner in which human infections respond to …

The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue
provides crucial insights into the pathophysiology of severe disease. From basic histology to …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Inhibition of heat shock protein 90 (Hsp90), a prominent molecular chaperone, effectively
limits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but little is …