Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS–STING) signaling
pathway, as vital component of innate immune system, acts a vital role in distinguishing …

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …

Objectives Dual specificity phosphatase 1 (DUSP1) is regarded as an anti-inflammatory
factor in cardiovascular disorders. Mitophagy removes damaged mitochondria and thus …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Di (2-ethylhexyl) phthalate (DEHP) is a highly harmful and persistent environmental
pollutant. Due to its unique chemical composition, it frequently dissolves and enters the …

With aging, the incidence of age-related diseases increases. Hence, age-related diseases
are inevitable. However, the mechanisms by which aging leads to the onset and progression …

It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD).
Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component …

Fucoidan (FU) is a natural polymer from marine organisms, which has been widely studied
and applied in drug delivery. In this study, FU nanoparticles loaded with proanthocyanidins …