Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments

ZM Liu, MH Yang, K Yu, ZX Lian… - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects
humans and animals which make coronavirus disease 2019 (COVID-19) a grievous …

SARS-CoV-2: receptor and co-receptor tropism probability

N Eslami, PS Aghbash, A Shamekh… - Current …, 2022 - Springer
The recent pandemic which arose from China, is caused by a pathogenic virus named
“severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)”. Its rapid global …

Toll-like receptor 4 in COVID-19: friend or foe?

S Mukherjee - Future Virology, 2022 - Taylor & Francis
Tweetable abstract Toll-like receptor 4, an innate immune sensor, is one of the key 'fate-
deciding'regulators of immunity as well as COVID-19 immunopathogenesis. Suitable …

Clinical efficacy of nirmatrelvir and ritonavir combination for treating diabetic patients with COVID‐19

JY Wu, MY Liu, TH Liu, MH Chuang… - Journal of Medical …, 2023 - Wiley Online Library
The aim of this study was to investigate the clinical efficacy of a combination of nirmatrelvir
and ritonavir (NMV‐r) for treating COVID‐19 in patients with diabetes mellitus (DM). This …

Comparative Binding Ability of Human Monoclonal Antibodies against Omicron Variants of SARS-CoV-2: An In Silico Investigation

NC Das, P Chakraborty, J Bayry, S Mukherjee - Antibodies, 2023 - mdpi.com
Mutation (s) in the spike protein is the major characteristic trait of newly emerged SARS-CoV-
2 variants such as Alpha (B. 1.1. 7), Beta (B. 1.351), Gamma (P. 1), Delta (B. 1.617. 2), and …

SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19

S Sahanic, R Hilbe, C Dünser, P Tymoszuk… - Heliyon, 2023 - cell.com
Abstract Background Toll-like receptors (TLRs) play a pivotal role in the immunologic
response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Association between the expression of toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity

W Alturaiki, H Alkadi, S Alamri, ME Awadalla, A Alfaez… - Heliyon, 2023 - cell.com
The recent identification of the involvement of the immune system response in the severity
and mortality of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection highlights …

Systematic review and meta‐analysis on the serological, immunological, and cardiac parameters of the multisystem inflammatory syndrome (MIS‐C) associated with …

G Ghazizadeh Esslami, S Mamishi… - Journal of Medical …, 2023 - Wiley Online Library
Diverse clinical and laboratory features of multisystem inflammatory syndrome (MIS‐C) have
been reported in the literature. Despite the worldwide distribution, systemic studies …

Clinical and electrocardiographic correlates of myocardial dysfunction after COVID‐19 in nonhospitalised patients in long‐term follow‐up. Data from the polish long …

J Kapusta, M Babicki… - Journal of Medical …, 2023 - Wiley Online Library
Clinical evidence indicates that COVID‐19 is a multiorgan disease that significantly impacts
the cardiovascular system. However, little is known about the predictors of myocardial …

Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection

R Chourasia, S Padhi, LC Phukon, MM Abedin… - …, 2022 - Taylor & Francis
Betacoronaviruses (β-CoVs) have caused major viral outbreaks in the last two decades in
the world. The mutation and recombination abilities in β-CoVs resulted in zoonotic diseases …