Nonsteroidal anti-inflammatory drugs and glucocorticoids in COVID-19

E Ricciotti, K Laudanski, GA FitzGerald - Advances in Biological Regulation, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is characterized by a wide spectrum of symptom …

Estrogen receptor modulators in viral infections such as SARS− CoV− 2: therapeutic consequences

N Abramenko, F Vellieux, P Tesařová, Z Kejík… - International Journal of …, 2021 - mdpi.com
COVID-19 is a pandemic respiratory disease caused by the SARS− CoV− 2 coronavirus.
The worldwide epidemiologic data showed higher mortality in males compared to females …

Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?

S Chatterjee, M Bhattacharya, K Dhama, SS Lee… - … Therapy-Nucleic Acids, 2023 - cell.com
The world has faced 3 years of the COVID-19 pandemic with billions of infections, millions of
deaths, and a massive economic crisis. Since the pandemic began, scientists have started to …

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+ monocytes and memory CD8+ T cells involved in severe COVID-19

Y Ma, F Qiu, C Deng, J Li, Y Huang, Z Wu, Y Zhou… - Genome Medicine, 2022 - Springer
Background Understanding the host genetic architecture and viral immunity contributes to
the development of effective vaccines and therapeutics for controlling the COVID-19 …

Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing

MA Islam, MK Kibria, MB Hossen, MS Reza… - Scientific Reports, 2023 - nature.com
Some recent studies showed that severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infections and idiopathic pulmonary fibrosis (IPF) disease might stimulate each other …

DE-MHAIPs: Identification of SARS-CoV-2 phosphorylation sites based on differential evolution multi-feature learning and multi-head attention mechanism

M Wang, L Yan, J Jia, J Lai, H Zhou, B Yu - Computers in Biology and …, 2023 - Elsevier
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around
the world affects the normal lives of people all over the world. The computational methods …

Exploring the therapeutic potential of SGLT2 inhibitors in cancer treatment: integrating in silico and in vitro investigations

P Mohite, DK Lokwani, NS Sakle - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
The present study aimed to investigate the anti-cancer mechanism of canagliflozin (CANA)
and dapagliflozin (DAPA), sodium-glucose co-transporter-2 (SGLT2) inhibitors, using in …

Molecular docking and molecular dynamic simulation approaches for drug development and repurposing of drugs for severe acute respiratory syndrome-Coronavirus …

P Subhaswaraj, B Siddhardha - … and diagnostic designing to mitigate SARS …, 2022 - Elsevier
The world is witnessing the impact of deadly disease outbreaks in the form of the novel
severe acute respiratory syndrome (SARS) like Coronavirus disease-2019 (COVID-19) …

Nimotuzumab for COVID-19: case series

AA Abdo Cuza, J Pi Avila, R Machado Martinez… - …, 2022 - Taylor & Francis
Background: In COVID-19, EGFR production is upregulated in the alveolar epithelial cells.
EGFR overexpression further activates STAT-3 and increases lung pathology. The EGFR …

The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics

HT Nguyen, VM Do, TT Phan… - … and Biology Insights, 2023 - journals.sagepub.com
The current coronavirus disease 2019 (COVID-19) outbreak is alarmingly escalating and
raises challenges in finding efficient compounds for treatment. Repurposing phytochemicals …