With the goal of representing common denominators of aging in different organisms López-
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …

Aging can be defined as a state of progressive functional decline accompanied by an
increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Age-associated chronic inflammation (inflammageing) is a central hallmark of ageing, but its
influence on specific cells remains largely unknown. Fibroblasts are present in most tissues …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

As aging and tumorigenesis are tightly interconnected biological processes, targeting their
common underlying driving pathways may induce dual‐purpose anti‐aging and anti‐cancer …

Multifaceted and divergent manifestations across tissues and cell types have curtailed
advances in deciphering the cellular events that accompany advanced age and contribute to …

Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

Aging is accompanied by disrupted information flow, resulting from accumulation of
molecular mistakes. These mistakes ultimately give rise to debilitating disorders including …

Aging is progressive physiological degeneration and consequently declined function, which
is linked to senescence on both cellular and organ levels. Accumulating studies indicate that …