Inhaled medicines: past, present, and future

S Anderson, P Atkins, P Bäckman, D Cipolla… - Pharmacological …, 2022 - ASPET
The purpose of this review is to summarize essential pharmacological, pharmaceutical, and
clinical aspects in the field of orally inhaled therapies that may help scientists seeking to …

Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Leucine as an excipient in spray dried powder for inhalation

N Alhajj, NJ O'Reilly, H Cathcart - Drug Discovery Today, 2021 - Elsevier
Leucine is a promising excipient with several applications in the development of inhalable
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …

[HTML][HTML] Design and application in delivery system of intranasal antidepressants

J Xu, J Tao, J Wang - Frontiers in Bioengineering and Biotechnology, 2020 - frontiersin.org
One of the major reasons why depressed patients fail their treatment course is the existence
of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central …

[HTML][HTML] Recent developments in lactose blend formulations for carrier-based dry powder inhalation

GA Hebbink, M Jaspers, HJW Peters… - Advanced Drug Delivery …, 2022 - Elsevier
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI)
formulations. Numerous inhalation therapies have been developed using lactose as a …

[HTML][HTML] Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties

N Alhajj, NJ O'Reilly, H Cathcart - Powder Technology, 2021 - Elsevier
Spray drying is a constructive single-step manufacturing technique used to produce dry
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …

Application of PLGA as a biodegradable and biocompatible polymer for pulmonary delivery of drugs

R Mahar, A Chakraborty, N Nainwal, R Bahuguna… - AAPS …, 2023 - Springer
Pulmonary administration of biodegradable polymeric formulation is beneficial in the
treatment of various respiratory diseases. For respiratory delivery, the polymer must be non …

Dry Powder Inhaler with the technical and practical obstacles, and forthcoming platform strategies

SS Gaikwad, SR Pathare, MA More… - Journal of Controlled …, 2023 - Elsevier
Abstract A Dry Powder Inhaler (DPI) is a technique as well as a device used to inhale
formulation which is in the form of dry powder, and is inhaled through the nose or mouth. It …

[HTML][HTML] Dry powder inhalers in the digitalization era: current status and future perspectives

S Xiroudaki, A Schoubben, S Giovagnoli, DM Rekkas - Pharmaceutics, 2021 - mdpi.com
During the last decades, the term “drug delivery systems”(DDSs) has almost fully replaced
previously used terms, such as “dosage forms”, in an attempt to emphasize the importance …

Drug combinations for inhalation: Current products and future development addressing disease control and patient compliance

H Banat, R Ambrus, I Csóka - International Journal of Pharmaceutics, 2023 - Elsevier
Pulmonary delivery is an alternative route of administration with numerous advantages over
conventional routes of administration. It provides low enzymatic exposure, fewer systemic …