Scientific and regulatory activities initiated by the US Food and Drug Administration to foster approvals of generic dry powder inhalers: quality perspective
N El-Gendy, CM Bertha, M Abd El-Shafy… - Advanced Drug Delivery …, 2022 - Elsevier
Regulatory science for generic dry powder inhalation products worldwide has evolved over
the last decade. The revised draft guidance Metered Dose Inhaler (MDI) and Dry Powder …
the last decade. The revised draft guidance Metered Dose Inhaler (MDI) and Dry Powder …
Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder respiratory delivery
Particle engineering via spray drying was used to develop a dry powder presentation of an
adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose …
adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose …
Cylindrical microparticles composed of mesoporous silica nanoparticles for the targeted delivery of a small molecule and a macromolecular drug to the lungs …
T Fischer, I Winter, R Drumm, M Schneider - Pharmaceutics, 2021 - mdpi.com
The transport of macromolecular drugs such as oligonucleotides into the lungs has become
increasingly relevant in recent years due to their high potency. However, the chemical …
increasingly relevant in recent years due to their high potency. However, the chemical …
Pulmonary delivery of spray-dried Nisin ZP antimicrobial peptide for non-small cell lung cancer (NSCLC) treatment
Nisin ZP is an antimicrobial peptide (AMP) produced by the bacterium Lactococcus lactis,
and we have previously demonstrated anticancer activity in NSCLC (A549) cells. In this …
and we have previously demonstrated anticancer activity in NSCLC (A549) cells. In this …
Combination and nanotechnology based pharmaceutical strategies for combating respiratory bacterial biofilm infections
L Zhang, H Bera, H Wang, J Wang, Y Guo, C Shi… - International Journal of …, 2022 - Elsevier
Respiratory infections are one of the major global health problems. Among them, chronic
respiratory infections caused by biofilm formation are difficult to treat because of both drug …
respiratory infections caused by biofilm formation are difficult to treat because of both drug …
[HTML][HTML] Characterization of Grape Pomace Extract Microcapsules: The Influence of Carbohydrate Co-Coating on the Stabilization of Goat Whey Protein as a Primary …
G Perković, J Martinović, G Šelo, A Bucić-Kojić… - Foods, 2024 - mdpi.com
Both grape pomace and whey are waste products from the food industry that are rich in
valuable ingredients. The utilization of these two by-products is becoming increasingly …
valuable ingredients. The utilization of these two by-products is becoming increasingly …
Inhalable hydrophilic molecule-loaded liposomal dry powder formulations using supercritical CO2–assisted spray-drying
Liposomes are known to be one of the most promising drug delivery systems for carrying
and delivering biopharmaceuticals. Yet, both liposomes and biopharmaceuticals are …
and delivering biopharmaceuticals. Yet, both liposomes and biopharmaceuticals are …
Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes
Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals
inside liposomes (CNL) were recently developed. In the present study, the storage stability …
inside liposomes (CNL) were recently developed. In the present study, the storage stability …
Formulation of dry powders for inhalation comprising high doses of a poorly soluble hydrophobic drug
Spray-dried formulations of a hydrophobic, crystalline drug, GDC-A, were prepared using
the suspension-PulmoSphere™ technology. Increases in drug loading resulted in …
the suspension-PulmoSphere™ technology. Increases in drug loading resulted in …
Co-spray dried nafamostat mesylate with lecithin and mannitol as respirable microparticles for targeted pulmonary delivery: pharmacokinetics and lung distribution in …
JH Kang, YJ Kim, MS Yang, DH Shin, DW Kim, IY Park… - Pharmaceutics, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by a new strain of coronavirus called severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …