Co-spray dried nafamostat mesylate with lecithin and mannitol as respirable microparticles for targeted pulmonary delivery: pharmacokinetics and lung distribution in …

JH Kang, YJ Kim, MS Yang, DH Shin, DW Kim, IY Park… - Pharmaceutics, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by a new strain of coronavirus called severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …

[HTML][HTML] Bacteriophage endolysin powders for inhaled delivery against pulmonary infections

Y Wang, D Khanal, AB Alreja, H Yang… - International Journal of …, 2023 - Elsevier
Endolysins are bacteriophage-encoded enzymatic proteins that have great potential to treat
multidrug-resistant bacterial infections. Bacteriophage endolysins Cpl-1 and ClyJ-3 have …

Storage stability of phage-ciprofloxacin combination powders against Pseudomonas aeruginosa respiratory infections

Y Lin, RYK Chang, WJ Britton, S Morales… - International Journal of …, 2020 - Elsevier
Novel inhalable and synergistic combination powder formulations of phage PEV20 and
ciprofloxacin were recently developed to treat Pseudomonas aeruginosa respiratory …

Inhalation dosage forms: a focus on dry powder inhalers and their advancements

S Magramane, K Vlahović, P Gordon, N Kállai-Szabó… - Pharmaceuticals, 2023 - mdpi.com
In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on
their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary …

[HTML][HTML] Numerical prediction of long-term stability of liquid formulations determined by visual observation and static multiple light scattering

MPL Sentis, B Aracil, G Lemahieu, M Bouzaid… - Colloids and Surfaces A …, 2023 - Elsevier
The demonstration of long-term stability is a key step when developing liquid formulation
because it has a major impact on product shelf life, transport, and end-use properties. Long …

Stability of inhaled ciprofloxacin-loaded poly (2-ethyl-2-oxazoline) nanoparticle dry powder inhaler formulation in high stressed conditions

MZR Sabuj, MA Rashid, TR Dargaville, N Islam - Pharmaceuticals, 2022 - mdpi.com
In this study, the stability of ciprofloxacin (CIP)-loaded poly (2-ethyl-2-oxazoline)(PEtOx)
nanoparticles (NPs) was investigated at normal and high stressed conditions. The blank …

Pulmonary targeting of levofloxacin using microsphere-based dry powder inhalation

T Al Hagbani, B Vishwa, AS Abu Lila, HF Alotaibi… - Pharmaceuticals, 2022 - mdpi.com
The objective of the current study was to develop poly (lactic-co-glycolic acid)(PLGA)
microspheres loaded with the anti-tuberculosis (anti-TB) fluoroquinolone, Levofloxacin …

Investigation of Physico-Chemical Stability and Aerodynamic Properties of Novel “Nano-in-Micro” Structured Dry Powder Inhaler System

P Party, R Ambrus - Micromachines, 2023 - mdpi.com
Pulmonary drug transport has numerous benefits. Large surface areas for absorption and
limited drug degradation of the gastrointestinal system are provided through the respiratory …

Raman spectroscopic evaluation of crystallinity, chemical composition and stability of pharmaceutical powder aerosols

D Khanal, WR Ke, HK Chan - International Journal of Pharmaceutics, 2022 - Elsevier
Raman spectroscopy was used to evaluate the effects of temperature and humidity on the
physicochemical stability of inhalable spray-dried (SD) powders containing budesonide …

Development of spray-dried N-acetylcysteine dry powder for inhalation

L Mancini, M Paolantoni, A Schoubben… - International Journal of …, 2023 - Elsevier
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been
used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its …