The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of
a blood vessel in the brain, thereby restricting blood supply to the area in question, and …

The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular
endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

The contribution of microglia to ischemic cortical stroke is of particular therapeutic interest
because of the impact on the survival of brain tissue in the ischemic penumbra, a region that …

Pericytes are branched cells located in the wall of capillary blood vessels that are found
throughout the body, embedded within the microvascular basement membrane and …

Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has
garnered considerable public attention due to the potential of returning tissues and organs …

Pericytes are functional components of the neurovascular unit (NVU). They provide support
to other NVU components and maintain normal physiological functions of the blood-brain …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …