Cell motion is crucial in human health and development. Cells may migrate individually or in
highly coordinated groups. Cell motion results from complex intra-and extra-cellular …

Gliomas are the most frequent primary brain tumors and include a variety of different
histological tumor types and malignancy grades. Recent achievements in terms of molecular …

The collection of 3D cell tracking data from live images of micro-tissues is a recent
innovation made possible due to advances in imaging techniques. As such there is …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Kinetic parameter estimates for mathematical models of glioblastoma multiforme (GBM),
derived from clinical scans, have been used to predict the occurrence of hypoxia, necrosis …

Malignant glioma is one of the most common primary brain tumors and is among the
deadliest of human cancers. The molecular mechanism for human glioma is poorly …

Background Contemporary biological observations have revealed a large variety of
mechanisms acting during the expansion of a tumor. However, there are still many …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of biomolecular data on cancer that now …

Studying cell motility is of vital importance for health, for knowing how cells behave and are
affected by, and can themselves cause, disease. Mathematical modelling of such behaviour …

Part I of this thesis aims at developing an extensible and computationally efficient framework
for in silico modeling of tumor growth in a 3-dimensional, inhomogeneous and time-varying …