Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation

R Du, S Tripathi, H Najem, DJ Brat, RV Lukas, P Zhang… - Cells, 2024 - mdpi.com
Macrophages and microglia are professional phagocytes that sense and migrate toward “eat-
me” signals. The role of phagocytic cells is to maintain homeostasis by engulfing senescent …

Role of NLRP3 in Parkinson's disease: Specific activation especially in dopaminergic neurons

J Yu, Z Zhao, Y Li, J Chen, N Huang, Y Luo - Heliyon, 2024 - cell.com
Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms like
bradykinesia, tremors, and balance issues. The pathology is recognized by progressively …

An “All‐In‐One” Immunomodulator‐Engineered Clinical Translatable Immunotherapy of Advanced Hepatocellular Carcinoma

T Xie, C Huang, Y Wang, H Zhang… - Advanced …, 2024 - Wiley Online Library
Clinical treatment of advanced hepatocellular carcinoma (HCC) remains a significant
challenge. Utilizing 1‐bromoacetyl‐3, 3‐dinitroazetidine (RRx‐001) to downregulate the …

Comprehensive Analysis of Predictive Value and the potential therapeutic target of NLRP3 inflammasome in glioma based on tumor microenvironment

B Li, Y Liu, D Chen, S Sun - Clinical Immunology, 2024 - Elsevier
Background Glioma exhibits high recurrence rates and poor prognosis. The nucleotide-
binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a …

Cellular Components of the Tumor Environment in Gliomas—What Do We Know Today?

R Nafe, E Hattingen - Biomedicines, 2023 - mdpi.com
A generation ago, the molecular properties of tumor cells were the focus of scientific interest
in oncology research. Since then, it has become increasingly apparent that the tumor …

Clinical research progress on RRx-001

G Yangyang, LOU Chunyang, Z Huojun… - 药学实践与 …, 2024 - yxsj.smmu.edu.cn
It is difficult to treat malignant tumors, neurodegenerative diseases, and vascular diseases.
For pathogenesis complexity of these diseases, researchers have focused on finding more …