Hyaluronic acid in ocular drug delivery

X Zhang, D Wei, Y Xu, Q Zhu - Carbohydrate Polymers, 2021 - Elsevier
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective

RS Dave, TC Goostrey, M Ziolkowska… - Journal of Controlled …, 2021 - Elsevier
There is a growing demand for effective treatments for ocular conditions that improve patient
compliance and reduce side-effects. While methods such as implants and injections have …

Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo

JD Friedl, V Nele, G De Rosa… - Advanced functional …, 2021 - Wiley Online Library
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …

Hyaluronic-coated albumin nanoparticles for the non-invasive delivery of apatinib in diabetic retinopathy

SES Radwan, A El-Kamel, EI Zaki… - International Journal …, 2021 - Taylor & Francis
Purpose Apatinib (Apa) is a novel anti-vascular endothelial growth factor with the potential to
treat diabetic retinopathy (DR); a serious condition leading to visual impairment and …

Effect of pea protein isolate incorporation on 3D printing performance and tailing effect of banana paste

Y Kim, HW Kim, HJ Park - Lwt, 2021 - Elsevier
Fruits have been used as potential food ingredients for the 3D printing of customized food for
the elderly or infants. However, the tailing effect observed in the long paste extrusion of fruits …

[HTML][HTML] Multifunctional naturally derived bioadhesives: from strategic molecular design toward advanced biomedical applications

M Kharaziha, T Scheibel, S Salehi - Progress in Polymer Science, 2024 - Elsevier
In the last decades, adhesives derived from natural resources (ie, bioadhesives) have
emerged as promising alternative to the standard wound closure devices, including sutures …

Review of approaches for increasing ophthalmic bioavailability for eye drop formulations

OL Lanier, MG Manfre, C Bailey, Z Liu, Z Sparks… - Aaps Pharmscitech, 2021 - Springer
Ophthalmic diseases represent a significant problem as over 2 billion people worldwide
suffer from vison impairment and blindness. Eye drops account for around 90% of …

Recent advances in the design of topical ophthalmic delivery systems in the treatment of ocular surface inflammation and their biopharmaceutical evaluation

R Mazet, JBG Yaméogo, D Wouessidjewe… - Pharmaceutics, 2020 - mdpi.com
Ocular inflammation is one of the most common symptom of eye disorders and diseases.
The therapeutic management of this inflammation must be rapid and effective in order to …

Advances in biodegradable nano-sized polymer-based ocular drug delivery

C Lynch, PPD Kondiah, YE Choonara, LC du Toit… - Polymers, 2019 - mdpi.com
The effective delivery of drugs to the eye remains a challenge. The eye has a myriad of
defense systems and physiological barriers that leaves ocular drug delivery systems with …

Hyaluronic acid: Its versatile use in ocular drug delivery with a specific focus on hyaluronic acid-based polyelectrolyte complexes

S Casey-Power, R Ryan, G Behl, P McLoughlin… - Pharmaceutics, 2022 - mdpi.com
Extensive research is currently being conducted into novel ocular drug delivery systems
(ODDS) that are capable of surpassing the limitations associated with conventional …