The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the
native regenerative properties of skeletal muscle and results in lifelong functional deficits …

The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …

The epidermis functions in skin as first defense line or barrier against environmental
impacts, resting on extracellular matrix (ECM) of the dermis underneath. Both compartments …

Developing neurons use a combination of guidance cues to assemble a functional neural
network. A variety of proteins immobilized within the extracellular matrix (ECM) provide …

The formation of highly efficient and reliable synapses at the neuromuscular junction (NMJ)
relies on dynamic molecular interactions. Studies of the development and maturation of the …

In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and
functional roles in essentially all organs, so understanding ECM protein organization in …

The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between
motoneuron and skeletal muscle, is characterized by a protracted postnatal period of …