Ferroptotic therapy in cancer: benefits, side effects, and risks

J Diao, Y Jia, E Dai, J Liu, R Kang, D Tang, L Han… - Molecular Cancer, 2024 - Springer
Ferroptosis is a type of regulated cell death characterized by iron accumulation and
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …

[PDF][PDF] Ferroptosis: principles and significance in health and disease

F Chen, R Kang, D Tang, J Liu - Journal of Hematology & Oncology, 2024 - Springer
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …

Aging and cancer

L Montégut, C López-Otín, G Kroemer - Molecular Cancer, 2024 - Springer
Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …

[HTML][HTML] Protein modification and degradation in ferroptosis

Y Wang, D Yan, J Liu, D Tang, X Chen - Redox Biology, 2024 - Elsevier
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …

Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway

J Liu, Y Wang, L Zeng, C Yu, R Kang, DJ Klionsky… - Autophagy, 2024 - Taylor & Francis
Sepsis, a life-threatening condition resulting from a dysregulated response to pathogen
infection, poses a significant challenge in clinical management. Here, we report a novel role …

Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges

J Liu, D Tang, R Kang - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Selenoprotein glutathione peroxidase 4 (GPX4) serves as a crucial suppressor of
oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here …

Ciprofloxacin is a novel anti-ferroptotic antibiotic

F Chen, H Tang, J Lin, R Kang, D Tang, J Liu - Heliyon, 2024 - cell.com
Cancer patients undergoing chemotherapy are susceptible to various bacterial infections,
necessitating prompt and precise antimicrobial treatment with antibiotics. Ciprofloxacin is a …

In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy …

P Lenzi, G Lazzeri, M Ferrucci, CL Busceti… - Journal of Neural …, 2024 - Springer
Neurodegenerative disorders are typically featured by the occurrence of neuronal
inclusions. In the case of Parkinson's disease (PD) these correspond to Lewy bodies (LBs) …

Sperm freezing damage: the role of regulated cell death

E Hai, B Li, J Zhang, J Zhang - Cell Death Discovery, 2024 - nature.com
Substantial progress in research on sperm cryopreservation has occurred since the
twentieth century, especially focusing on improving sperm freezing procedures and …

Mutations in EPG5 are associated with a wide spectrum of neurodevelopmental and neurodegenerative disorders

HS Dafsari, C Deneubourg, K Singh, R Maroofian… - medRxiv, 2024 - medrxiv.org
Autophagy is a fundamental and evolutionary conserved biological pathway with vital roles
in intracellular quality control and homeostasis. The process of autophagy involves the …