Single-cell immunology of SARS-CoV-2 infection

Y Tian, LN Carpp, HER Miller, M Zager… - Nature …, 2022 - nature.com
Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …

COVID-19 inflammation and implications in drug delivery

M Zoulikha, F Huang, Z Wu, W He - Journal of Controlled Release, 2022 - Elsevier
Growing evidence indicates that hyperinflammatory syndrome and cytokine storm observed
in COVID-19 severe cases are narrowly associated with the disease's poor prognosis …

A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome

A Taher, M Lashgari, L Sedighi, F Rahimi-Bashar… - Pharmacological …, 2021 - Springer
Background We designed this single-centre clinical trial to assess the potential benefits of N-
Acetylcysteine (NAC) in patients with COVID19-associated acute respiratory distress …

A centenary tale of two pandemics: The 1918 influenza pandemic and COVID-19, Part II

DM Morens, JK Taubenberger… - American Journal of …, 2021 - ajph.aphapublications.org
Both the 1918 influenza pandemic and the 2019‒2021 COVID-19 pandemic are among the
most disastrous infectious disease emergences of modern times. In addition to similarities in …

Evolutionary conflicts and adverse effects of antiviral factors

D Sauter, F Kirchhoff - Elife, 2021 - elifesciences.org
Human cells are equipped with a plethora of antiviral proteins protecting them against
invading viral pathogens. In contrast to apoptotic or pyroptotic cell death, which serves as …

An overview on tumor treating fields (TTFields) technology as a new potential subsidiary biophysical treatment for COVID-19

AR Farmani, F Mahdavinezhad, C Scagnolari… - Drug Delivery and …, 2022 - Springer
COVID-19 pandemic situation has affected millions of people with tens of thousands of
deaths worldwide. Despite all efforts for finding drugs or vaccines, the key role for the …

Metacell-based differential expression analysis identifies cell type specific temporal gene response programs in COVID-19 patient PBMCs

K O'Leary, D Zheng - NPJ Systems Biology and Applications, 2024 - nature.com
By profiling gene expression in individual cells, single-cell RNA-sequencing (scRNA-seq)
can resolve cellular heterogeneity and cell-type gene expression dynamics. Its application to …

[HTML][HTML] Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments

EK Sher, M Alebić, MM Boras, E Boškailo… - International Journal of …, 2024 - Elsevier
Advancements in nanotechnology were vastly applied in medicine and pharmacy,
especially in the field of nano-delivery systems. It took a long time for these systems to …

Therapeutic Approaches in COVID‐19 Patients: The Role of the Renin‐Angiotensin System

F Ketabchi, S Jamzad - Canadian Respiratory Journal, 2022 - Wiley Online Library
Two and a half years after COVID‐19 was first reported in China, thousands of people are
still dying from the disease every day around the world. The condition is forcing physicians …

Alleviative Effect of Geniposide on Lipopolysaccharide-Stimulated Macrophages via Calcium Pathway

HJ Kim, W Park - International Journal of Molecular Sciences, 2024 - mdpi.com
In this study, we investigated how geniposide (a bioactive ingredient of gardenia fruit) acts
on lipopolysaccharide (LPS)-stimulated macrophages. Griess reagent assay, Fluo-4 calcium …