Most animals alternate periods of feeding with periods of fasting often coinciding with sleep.
Upon> 24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Objective Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian
photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We …

The prevention or delay of the onset of age-related diseases prolongs survival and improves
quality of life while reducing the burden on the health care system. Activation of sirtuin 1 …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its
beneficial effects remain unknown. The manner in which CR has been implemented in …

Circadian rhythms align physiological functions with the light–dark cycle through oscillatory
changes in the abundance of proteins in the clock transcriptional programme. Timely …

The circadian clock, an internal time-keeping system, has been linked with control of aging,
but molecular mechanisms of regulation are not known. BMAL1 is a transcriptional factor …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

The mammalian circadian clock system, which includes the master clock and peripheral
clocks, times different biological processes in reaction to external cues, such as the light …