The aim of this study was to identify key candidate genes in prostate cancer. The gene
expression profiles of GSE32448, GSE45016, GSE46602 and GSE104749 were …

Prostate cancer (PCa) is a highly prevalent malignancy and constitutes a major cause of
cancer-related morbidity and mortality. It emerges through the acquisition of genetic and …

Urological cancers are common malignant cancers worldwide, with annually increasing
morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models …

ABSTRACT Introduction Prostate cancer (PCa) is a complex, heterogenous and multifocal
disease, which is debilitating for patients and often fatal–due to bone metastasis and …

Improved prostate cancer detection methods would avoid over-diagnosis of clinically
indolent disease informing appropriate treatment decisions. The aims of this study were to …

While chronic inflammation has been causally associated with several epithelial
malignancies, whether it causally contributes to the development of prostate cancer has …

Background RNA-seq data are increasingly used to derive prognostic signatures for cancer
outcome prediction. A limitation of current predictors is their reliance on reference gene …

Age is a significant risk factor for disease of the prostate. However, the mechanisms by
which age increases disease risk have not been well described. We previously reported age …

Background The composition of the tumor microbial microenvironment participates in the
whole process of tumor disease. However, due to the limitations of the current technical …

Organ development, regeneration and cancer initiation are typically influenced by the
proliferation and lineage plasticity of tissue-specific stem cells. Prostate intermediate cells …