Purpose: Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity
of genetic drivers. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib …

Non‑small cell lung cancer (NSCLC), which accounts for~ 85% of all lung cancer cases, is
commonly diagnosed at an advanced stage and has a high patient mortality rate. Despite …

The proliferative capacity and continuous survival of cells are highly dependent on
telomerase expression and the maintenance of telomere length. For this reason, elevated …

Multiple independent sequence variants of the hTERT locus have been associated with
telomere length and cancer risks in genome-wide association studies. Here, we identified an …

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase
reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins …

Telomerase activation is a crucial step in melanomagenesis, often occurring because of
ultraviolet radiation (UVR)‐induced mutations at the telomerase gene (TERT) promoter and …

Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic
landscape for metastatic melanoma patients bearing mutations in the BRAF kinase …

The human telomerase gene (hTERT) is repressed in most somatic cells. How transcription
factors activate the hTERT promoter in its repressive chromatin environment is unknown …

Telomerase is a ribonucleoprotein enzyme that synthesizes telomere end sequence. The
expression of hTERT gene, encoding the catalytic subunit of human telomerase, is restricted …

间充质干细胞(mesenchymal stem cells, MSCs) 具有多向分化潜能和免疫调节能力,
且不具伦理争议的特点使其数十年来在基础和临床研究中得到广泛应用. 然而, MSCs …