The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …

Background Several therapeutics have been developed and approved against SARS-CoV-2
occasionally; nirmatrelvir is one of them. The drug target of nirmatrelvir is Mpro, and …

ABSTRACT Introduction Nirmatrelvir/ritonavir (Paxlovid®) represent an oral antiviral therapy
approved for the treatment of COVID-19. Extensive in vitro and in vivo studies have reported …

Hyperpigmentation can occur in abnormal skin conditions such as melanomas, as well as in
conditions including melasma, freckles, age spots, seborrheic keratosis, and café-au-lait …

Bats carry genetically diverse severe acute respiratory syndrome-related coronaviruses
(SARSr-CoVs). Some of them utilize human angiotensin-converting enzyme 2 (hACE2) as a …

A computer-aided drug design of new derivatives of nirmatrelvir, an orally active inhibitor of
the main-protease (Mpro) of the severe acute respiratory syndrome Coronavirus 2 (SARS …

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface
(heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these …

Multiple coronaviruses (CoVs) can cause respiratory diseases in humans. While
prophylactic vaccines designed to prevent infection are available for severe acute …

Coronaviruses pose a permanent risk of outbreaks, with three highly pathogenic species
and strains (SARS-CoV, MERS-CoV, SARS-CoV-2) having emerged in the last twenty years …

The emergence of the COVID-19 pandemic prompted an increased interest in seasonal
human coronaviruses. OC43, 229E, NL63, and HKU1 are endemic seasonal coronaviruses …