Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

M Zhang, S Serna-Salas, T Damba… - Mechanisms of ageing …, 2021 - Elsevier
Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main
precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which …

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Y Koike, B Li, N Ganji, H Zhu, H Miyake, Y Chen… - Nature …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …

Effects of d‐galactose‐induced ageing on the heart and its potential interventions

C Bo‐Htay, S Palee, N Apaijai… - Journal of Cellular …, 2018 - Wiley Online Library
Ageing is a strong independent risk factor for disability, morbidity and mortality. Post‐mitotic
cells including those in the heart are a particular risk to age‐related deterioration. As the …

The p53/p21/p16 and PI3K/Akt signaling pathways are involved in the ameliorative effects of maltol on D‐galactose‐induced liver and kidney aging and injury

J Sha, J Li, Y Zhou, J Yang, W Liu, S Jiang… - Phytotherapy …, 2021 - Wiley Online Library
Successive evidence has established that maltol, a flavor‐enhancing agent, could provide
resistance to oxidative stress‐induced tissue injury in various animal models though its …

Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier …

H Chi, W Cao, M Zhang, D Su, H Yang, Z Li… - Journal of …, 2021 - Springer
Background Both genetic factors and environmental hazards, including environmental noise
stress, have been associated with gut microbiome that exacerbates Alzheimer's disease …

Role of hydrogen sulfide in cardiovascular ageing

L Testai, V Citi, A Martelli, S Brogi… - Pharmacological Research, 2020 - Elsevier
Cardiovascular diseases are the main cause of morbidity and mortality in the Western
society and ageing is a relevant non-modifiable risk factor. Morphological and functional …

Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner

YO Henderson, N Bithi, C Link, J Yang, R Schugar… - Geroscience, 2021 - Springer
Global average life expectancy continues to rise. As aging increases the likelihood of frailty,
which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for …

Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous

AS Sokolov, PV Nekrasov, MV Shaposhnikov… - Ageing research …, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is one of the biologically active gases (gasotransmitters), which
plays an important role in various physiological processes and aging. Its production in the …

Hydrogen sulfide signaling in regulation of cell behaviors

Y Wang, R Yu, L Wu, G Yang - Nitric Oxide, 2020 - Elsevier
Recent advances in the biomedical importance of H 2 S have help us understand various
cellular functions and pathophysiological processes from a new aspect. Specially, H 2 S has …