Genetically transitional disease: conceptual understanding and applicability to rheumatic disease

TB Niewold, I Aksentijevich, PD Gorevic… - Nature Reviews …, 2024 - nature.com
In genomic medicine, the concept of genetically transitional disease (GTD) refers to cases in
which gene mutation is necessary but not sufficient to cause disease. In this Perspective, we …

[HTML][HTML] B cell metabolism in autoimmune diseases: signaling pathways and interventions

J Li, M Zhao, W Luo, J Huang, B Zhao… - Frontiers in …, 2023 - frontiersin.org
Autoimmune diseases are heterogeneous disorders believed to stem from the immune
system's inability to distinguish between auto-and foreign-antigens. B lymphocytes serve a …

[HTML][HTML] B-cell activation biomarkers in salivary glands are related to lymphomagenesis in primary sjögren's disease: A pilot monocentric exploratory study

D Bruno, B Tolusso, G Lugli, C Di Mario… - International Journal of …, 2024 - mdpi.com
Primary Sjögren's disease is primarily driven by B-cell activation and is associated with a
high risk of developing non-Hodgkin's lymphoma (NHL). Over the last few decades …

CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis

J Zhou, JL Pathak, T Cao, B Chen, W Wei, S Hu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly
affects exocrine glands. Previous studies have demonstrated that upregulated interferon …

[HTML][HTML] Functional significance of DNA methylation: epigenetic insights into Sjögren's syndrome

Y Wang, F Riaz, W Wang, J Pu, Y Liang, Z Wu… - Frontiers in …, 2024 - frontiersin.org
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease
with a significant global prevalence. It is a complex condition that requires careful …

Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis

J Zhou, JL Pathak, L Wu, B Chen, T Cao, W Wei… - Free Radical Biology …, 2024 - Elsevier
Sjogren's syndrome (SS) is an autoimmune disease characterized by dysfunction of
exocrine glands, such as salivary glands. However, the molecular mechanism of salivary …

Cardiovascular Imaging in Women

S Massalha, J Kennedy, E Hussein, B Mahida… - Seminars in Nuclear …, 2024 - Elsevier
Multimodality cardiovascular imaging is a cornerstone diagnostic tool in the diagnosis, risk
stratification, and management of cardiovascular diseases, whether those involving the …

Exploring Salivary Epithelial Dysfunction in Sjögren's Disease

B Noll, M Beckman, F Bahrani Mougeot… - International Journal of …, 2024 - mdpi.com
Sjögren's Disease (SjD) is an autoimmune disease of the exocrine tissues. Etiological
events result in the loss of epithelial homeostasis alongside extracellular matrix (ECM) …

[PDF][PDF] Significance of N6-methyladenosine RNA methylation regulators in diagnosis and subtype classification of primary Sjögren's syndrome

J Li, K Xie, M Xu, Y Wang, Y Huang, T Tan, H Xie - Heliyon, 2024 - cell.com
The importance of N6-methyladenine (m6A) in mRNA metabolism, physiology, pathology
and other life processes is well recognized. However, the exact role of m6A regulators in …

New investigational drugs to treat Sjogren's syndrome: lessons learnt from immunology

X Zhou, D Xu, M Li, X Zeng - Expert Opinion on Investigational …, 2024 - Taylor & Francis
Introduction Sjögren's syndrome is a heterogeneous autoimmune condition that impairs
quality of life because of dryness, fatigue, pain, and systemic involvements. Current …