African sleeping sickness, Chagas disease, and leishmaniasis are life-threatening diseases
that together affect millions of people around the world and are caused by different members …

For many years, the purine salvage pathway of parasitic protozoa has been regarded as an
attractive chemotherapeutic target. Parasitic protozoa lack de novo synthesis and rely …

African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited
treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely …

The nucleoside antibiotic tubercidin displays strong activity against different target
organisms, but it is notoriously toxic to mammalian cells. The effects of tubercidin against T …

The concept of click chemistry represented by the formation of the 1, 2, 3-triazole core has
found wide application in drug discovery, particularly in the early discovery phases and the …

Kinetoplastid parasites are the causative agents of neglected tropical diseases with an
unmet medical need. These parasites are unable to synthesize the purine ring de novo, and …

Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to
nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria …

African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed
pyrimidines from the host. However, uptake of pyrimidines in bloodstream form …

C-Analogues of the canonical N-nucleosides have considerable importance in medicinal
chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic …

A series of 73 bisphosphonium salts and 10 monophosphonium salt derivatives were
synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma …