The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Background/Aim Cardiorespiratory fitness (CRF) is a strong determinant of morbidity and
mortality. In athletes and the general population, it is established that high-intensity interval …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Background—In animal models, brief periods of ischemia performed just at the time of
reperfusion can reduce infarct size, a phenomenon called postconditioning. In this …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15
minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 …

The heart is a tumor necrosis factor (TNF)-producing organ. Both myocardial macrophages
and cardiac myocytes themselves synthesize TNF. Accumulating evidence indicates that …

On July 2–3, 1996, the National Heart, Lung, and Blood Institute sponsored a workshop in
Columbia, Md, entitled “The Medical and Cellular Implications of Myocardial Stunning …

Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by
ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory …

Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the
process of tissue damage after myocardial infarction, which has pathological and …