Immune profiling reveals decreases in circulating regulatory and exhausted T cells in human hypertension

MR Alexander, BL Dale, CD Smart, F Elijovich… - Basic to Translational …, 2023 - jacc.org
Evidence from nonhuman animal models demonstrates an important role for immune cells in
hypertension, but immune cell changes in human hypertension are less clear. Using mass …

[HTML][HTML] Common themes in zoonotic spillover and disease emergence: Lessons learned from bat-and rodent-borne RNA viruses

EP Williams, BM Spruill-Harrell, MK Taylor, J Lee… - Viruses, 2021 - mdpi.com
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest
percentage of living mammals on earth. Thus, it is not surprising that these two orders …

[HTML][HTML] A novel single cell RNA-seq analysis of non-myeloid circulating cells in late sepsis

DB Darden, X Dong, MA Brusko, L Kelly… - Frontiers in …, 2021 - frontiersin.org
Background With the successful implementation of the Surviving Sepsis Campaign
guidelines, post-sepsis in-hospital mortality to sepsis continues to decrease. Those who …

[PDF][PDF] Immune exhaustion of T cells in alveolar echinococcosis patients and its reversal by blocking checkpoint receptor TIGIT in a murine model

C Zhang, R Lin, Z Li, S Yang, X Bi, H Wang, A Aini… - …, 2020 - Wiley Online Library
Background and Aims The cestode Echinococcus multilocularis infection, a serious health
problem worldwide, causes alveolar echinococcosis (AE), a tumor‐like disease …

[HTML][HTML] Hematological manifestations and complications of COVID-19

B Erdinc, S Sahni, V Gotlieb - Advances in Clinical and …, 2021 - advances.umw.edu.pl
The virus SARS-CoV-2 commonly causes self-resolving, flu-like illnesses in the majority of
patients, but a critical illness can be seen in 5% of cases–especially in the elderly population …

Cellular and molecular regulation of the programmed death-1/programmed death ligand system and its role in multiple sclerosis and other autoimmune diseases

J Ibañez-Vega, C Vilchez, K Jimenez, C Guevara… - Journal of …, 2021 - Elsevier
Abstract Programmed Cell Death 1 (PD-1) receptor and its ligands (PD-Ls) are essential to
maintain peripheral immune tolerance and to avoid tissue damage. Consequently, altered …

Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations

Y Tabana, TC Moon, A Siraki, S Elahi… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: T cell functions are altered during chronic viral infections and tumor
development. This is mainly manifested by significant changes in T cells' epigenetic and …

[HTML][HTML] Immunotherapeutic potential of T memory stem cells

Y Li, D Wu, X Yang, S Zhou - Frontiers in oncology, 2021 - frontiersin.org
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM).
Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better …

[HTML][HTML] Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19

B Liao, Z Liu, L Tang, L Li, Q Gan, H Shi… - … Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Rationale: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused
on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes of …

Longitudinal peripheral blood transcriptional analysis reveals molecular signatures of disease progression in COVID-19 patients

Q Yan, P Li, X Ye, X Huang, B Feng, T Ji… - The journal of …, 2021 - journals.aai.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients …