HIV infection alters the natural history of several cancers, in large part due to its effect on the
immune system. Immune function in people living with HIV may vary from normal to highly …

Lupus nephritis (LN), a chronic inflammatory disease, is characterized by the substantial
disruption of immune homeostasis. This study examines its effects on the T lymphocyte …

Simple Summary Metastatic renal cell carcinoma continues to have a poor prognosis.
Chemotherapies and immuno-oncologic therapies have garnered increasing importance in …

Background With the challenges that aging populations pose to health care, interventions
that facilitate alleviation of age-related morbidities are imperative. A prominent risk factor for …

Severe acute respiratory syndrome coronavirus 2 has spread rapidly around the globe.
However, despite its high pathogenicity and transmissibility, the severity of the associated …

The impairment of immunity characterized by T cell exhaustion is the main cause of death in
patients with sepsis after the acute phase. Although PD-1 blockade is highly touted as a …

The risk of severe COVID-19 increases with age as older patients are at highest risk. Thus,
there is an urgent need to identify how severe acute respiratory syndrome coronavirus 2 …

Immune checkpoints (ICPs) consist of paired receptor-ligand molecules that exert inhibitory
or stimulatory effects on immune defense, surveillance, regulation, and self-tolerance. ICPs …

Chimeric antigen receptor (CAR) T cells have emerged as a powerful therapeutic modality
for cancer. Following encouraging clinical results, autologous anti-CD19 CAR-T cells first …

Glycolipids constitute a major part of the cell envelope of Mycobacterium tuberculosis (Mtb).
They are potent immunomodulatory molecules recognized by several immune receptors like …