[HTML][HTML] Cancer bioenergetics and tumor microenvironments—Enhancing chemotherapeutics and targeting resistant niches through nanosystems

A Farhana, A Alsrhani, YS Khan, Z Rasheed - Cancers, 2023 - mdpi.com
Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …

[HTML][HTML] Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023 - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

LPCAT3 is transcriptionally regulated by YAP/ZEB/EP300 and collaborates with ACSL4 and YAP to determine ferroptosis sensitivity

J Cui, Y Wang, X Tian, Y Miao, L Ma… - Antioxidants & redox …, 2023 - liebertpub.com
Aims: Lipid peroxidation occurring in lung adenocarcinoma (LUAD) cells leads to
ferroptosis. Lysophosphatidylcholine acyl-transferase 3 (LPCAT3) plays a key role in …

[HTML][HTML] Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS …

Y Yan, X Yang, N Han, Y Liu, Q Liang, LG Li… - Journal of …, 2023 - Springer
Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia
annua, is recently used as a novel anti-cancer agent. However, some intrinsic …

[HTML][HTML] Antioxidant activity and inhibition of liver cancer cells' growth of extracts from 14 marine Macroalgae species of the Mediterranean Sea

N Goutzourelas, DP Kevrekidis, S Barda, P Malea… - Foods, 2023 - mdpi.com
Macroalgae exhibit beneficial bioactivities for human health. Thus, the aim of the present
study was to examine the antioxidant and anticancer potential of 14 macroalgae species' …

The interplay of miRNAs and ferroptosis in diseases related to iron overload

S Jin, PS Liu, D Zheng, X Xie - Apoptosis, 2024 - Springer
Ferroptosis has been conceptualized as a novel cell death modality distinct from apoptosis,
necroptosis, pyroptosis and autophagic cell death. The sensitivity of cellular ferroptosis is …

The crosstalk between oncogenic signaling and ferroptosis in cancer

Q Pang, Z Tang, L Luo - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Ferroptosis, a novel form of cell death regulation, was identified in 2012. It is characterized
by unique features that differentiate it from other types of cell death, including necrosis …

[HTML][HTML] The role of tRNA-centered translational regulatory mechanisms in cancer

Y Shi, Y Feng, Q Wang, G Dong, W Xia, F Jiang - Cancers, 2023 - mdpi.com
Simple Summary The protein translation machinery, of which tRNA is an essential part, is
critical in controlling the growth of tumor cells. The development of cancer is also influenced …

Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis

X Ma, Y Li, D Liang, F Jiang, L Zhang… - Journal of Pharmacy …, 2024 - academic.oup.com
Objectives Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer
worldwide. Solanine is a phytochemical extracted from traditional Chinese medicine with …

[HTML][HTML] Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

R Zhang, W Jiang, G Wang, Y Zhang, W Liu… - Communications …, 2024 - nature.com
PRKN is a key gene involved in mitophagy in Parkinson's disease. However, recent studies
have demonstrated that it also plays a role in the development and metastasis of several …