[HTML][HTML] Biodegradable polymeric nanoparticles for drug delivery to solid tumors

A Gagliardi, E Giuliano, E Venkateswararao… - Frontiers in …, 2021 - frontiersin.org
Advances in nanotechnology have favored the development of novel colloidal formulations
able to modulate the pharmacological and biopharmaceutical properties of drugs. The …

Approaches to minimize the effects of P‐glycoprotein in drug transport: A review

A Husain, V Makadia, GR Valicherla… - Drug development …, 2022 - Wiley Online Library
Abstract P‐glycoprotein (P‐gp) is a transporter protein that is come under the ATP binding
cassette family of proteins. It is situated on the surface of the intestine epithelium, where P …

[HTML][HTML] Liquid and solid self-emulsifying drug delivery systems (SEDDs) as carriers for the oral delivery of azithromycin: optimization, in vitro characterization and …

R Abou Assi, I M. Abdulbaqi, T Seok Ming, C Siok Yee… - Pharmaceutics, 2020 - mdpi.com
Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial
infections. The drug is known to have low oral bioavailability (37%) which may be attributed …

[HTML][HTML] Nanoparticulate drug delivery strategies to address intestinal cytochrome P450 CYP3A4 metabolism towards personalized medicine

RX Zhang, K Dong, Z Wang, R Miao, W Lu, XY Wu - Pharmaceutics, 2021 - mdpi.com
Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness,
is critical to patients' outcomes. However, many orally administered therapeutic drugs are …

Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection?

RP Dash, V Veeravalli, JA Thomas… - Future Medicinal …, 2021 - Taylor & Francis
In the present era of drug development, quantification of drug concentrations following
pharmacokinetic studies has preferentially been performed using plasma as a matrix rather …

Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10

T Chhitij, JE Seo, T Keum, G Noh, S Bashyal… - Drug Delivery, 2022 - Taylor & Francis
Our study aimed to develop a self-microemulsifying drug delivery system for the poorly
aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral …

Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs

J Xin, M Qin, G Ye, H Gong, M Li, X Sui… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Self-emulsifying drug delivery systems (SEDDS) are formulations consisting of
oil phase, emulsifiers, and co-emulsifiers, which can be spontaneously emulsified in the …

Natural product-based excipients for topical green formulations

LAL Silvério, JC Coco, LM de Macedo… - Sustainable Chemistry …, 2023 - Elsevier
The industry has been paying more attention to the quality of excipients since they play a
fundamental role in the efficacy, safety, and acceptability of pharmaceutical products …

Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver

HP Nagaiah, PD Periyakaruppan Murugesan… - The AAPS Journal, 2024 - Springer
Addressing the intertwined challenges of antimicrobial resistance and impaired wound
healing in diabetic patients, an oil/water emulsion-based nano-ointment integrating …

[HTML][HTML] Improving the sensitivity of estimating CBD and other xenobiotics in plasma samples: Oleamide-induced transient matrix effect

AL Dawidowicz, MP Dybowski, M Rombel… - … of Pharmaceutical and …, 2021 - Elsevier
The paper discusses the matrix effect evoked by oleamide (OLA), a compound frequently
found in samples processed and/or stored in lab polypropylene vials or disposable syringes …