A Husain, V Makadia, GR Valicherla… - Drug development …, 2022 - Wiley Online Library
Abstract P‐glycoprotein (P‐gp) is a transporter protein that is come under the ATP binding cassette family of proteins. It is situated on the surface of the intestine epithelium, where P …
Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial infections. The drug is known to have low oral bioavailability (37%) which may be attributed …
RX Zhang, K Dong, Z Wang, R Miao, W Lu, XY Wu - Pharmaceutics, 2021 - mdpi.com
Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness, is critical to patients' outcomes. However, many orally administered therapeutic drugs are …
RP Dash, V Veeravalli, JA Thomas… - Future Medicinal …, 2021 - Taylor & Francis
In the present era of drug development, quantification of drug concentrations following pharmacokinetic studies has preferentially been performed using plasma as a matrix rather …
T Chhitij, JE Seo, T Keum, G Noh, S Bashyal… - Drug Delivery, 2022 - Taylor & Francis
Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral …
J Xin, M Qin, G Ye, H Gong, M Li, X Sui… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Self-emulsifying drug delivery systems (SEDDS) are formulations consisting of oil phase, emulsifiers, and co-emulsifiers, which can be spontaneously emulsified in the …
The industry has been paying more attention to the quality of excipients since they play a fundamental role in the efficacy, safety, and acceptability of pharmaceutical products …
HP Nagaiah, PD Periyakaruppan Murugesan… - The AAPS Journal, 2024 - Springer
Addressing the intertwined challenges of antimicrobial resistance and impaired wound healing in diabetic patients, an oil/water emulsion-based nano-ointment integrating …
AL Dawidowicz, MP Dybowski, M Rombel… - … of Pharmaceutical and …, 2021 - Elsevier
The paper discusses the matrix effect evoked by oleamide (OLA), a compound frequently found in samples processed and/or stored in lab polypropylene vials or disposable syringes …