The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …

Both animal models and human observational and genetic studies have shown that immune
and inflammatory mechanisms play a key role in hypertension and its complications. We …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Background and aims Observational studies have linked elevated blood pressure (BP) to
impaired cognitive function. However, the functional and structural changes in the brain that …

Discovering novel uses for existing drugs, through drug repurposing, can reduce the time,
costs, and risk of failure associated with new drug development. However, prioritizing drug …

Many Mendelian randomization (MR) studies have been published recently, with inferences
on the causal relationships between risk factors and diseases that have potential …

Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …