The cardiovascular system in space: focus on in vivo and in vitro studies

R Baran, S Marchal, S Garcia Campos, E Rehnberg… - Biomedicines, 2021 - mdpi.com
On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

D Grimm, M Wehland, TJ Corydon… - Stem cells …, 2020 - academic.oup.com
A spaceflight has enormous influence on the health of space voyagers due to the combined
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …

A 3D‐bioprinted vascularized glioblastoma‐on‐a‐chip for studying the impact of simulated microgravity as a novel pre‐clinical approach in brain tumor therapy

G Silvani, C Basirun, H Wu, C Mehner… - Advanced …, 2021 - Wiley Online Library
Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and
urgently requires the development of new therapeutic strategies. In this study, an innovative …

Cardiac function, structural, and electrical remodeling by microgravity exposure

MR Sy, JA Keefe, JP Sutton… - American Journal of …, 2023 - journals.physiology.org
Space medicine is key to the human exploration of outer space and pushes the boundaries
of science, technology, and medicine. Because of harsh environmental conditions related to …

Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity

C Buken, J Sahana, TJ Corydon, D Melnik, J Bauer… - Scientific Reports, 2019 - nature.com
The literature suggests morphological alterations and molecular biological changes within
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

Extraterrestrial gynecology: could spaceflight increase the risk of developing cancer in female astronauts? An updated review

R Drago-Ferrante, R Di Fiore, F Karouia… - International journal of …, 2022 - mdpi.com
Outer space is an extremely hostile environment for human life, with ionizing radiation from
galactic cosmic rays and microgravity posing the most significant hazards to the health of …