Quercetin and ferroptosis

A Cruz-Gregorio, AK Aranda-Rivera - Life, 2023 - mdpi.com
Quercetin is a flavonoid present in apples, onions, tea, red wines, and berries, and it has
shown different beneficial effects, such as providing cardiovascular protection, possessing …

Natural flavonoids and ferroptosis: Potential therapeutic opportunities for human diseases

Z Zhou, J Li, X Zhang - Journal of Agricultural and Food Chemistry, 2023 - ACS Publications
Flavonoids are a class of bioactive phytochemicals containing a core 2-phenylchromone
skeleton and are widely found in fruits, vegetables, and herbs. Such natural compounds …

[HTML][HTML] A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

X Luo, X Weng, X Bao, X Bai, Y Lv, S Zhang, Y Chen… - Redox Biology, 2022 - Elsevier
Natural antioxidants represented by quercetin have been documented to be effective
against atherosclerosis. However, the related mechanisms remain largely unclear. In this …

Novel near-infrared fluorescence probe for bioimaging and evaluating superoxide anion fluctuations in ferroptosis-mediated epilepsy

W Yang, R Liu, X Yin, K Wu, Z Yan, X Wang… - Analytical …, 2023 - ACS Publications
Ferroptosis is an iron-regulated, caspase-mediated pathway of cell death that is associated
with the excessive aggregation of lipid-reactive oxygen species and is extensively involved …

Quercetin alleviates acrylamide-induced liver injury by inhibiting autophagy-dependent ferroptosis

T Huang, K Zhang, J Wang, K He… - Journal of Agricultural …, 2023 - ACS Publications
Acrylamide (ACR) generated in carbohydrate-rich foods during thermal processing has
been demonstrated to exhibit hepatotoxicity. As one of the most consumed flavonoids with …

[HTML][HTML] Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

B Zhou, Y Yang, X Pang, J Shi, T Jiang… - Biomedicine & …, 2023 - Elsevier
SIRT5 is a mitochondrial NAD+-dependent lysine deacylase. Downregulation of SIRT5 has
been linked to several primary cancers and DNA damage. In clinical therapy for non-small …

Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway

C Peng, Q Ai, F Zhao, H Li, Y Sun, K Tang… - European Journal of …, 2024 - Elsevier
Aims Ischemic stroke is a severe cerebrovascular disease in which neuronal death
continually occurs through multiple forms, including apoptosis, autophagy, pyroptosis and …

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

L Ding, S Dang, M Sun, D Zhou, Y Sun, E Li… - Free Radical Biology …, 2024 - Elsevier
Quercetin (Quer) is a natural flavonoid known for its inhibitory effects against various
cancers. However, the mechanism by which Quer inhibits gastric cancer (GC) has not yet …

Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage

S Ma, C Li, C Yan, N Liu, G Jiang, H Yang… - Free Radical Biology …, 2023 - Elsevier
Ferroptosis is a novel form of cell death that plays a critical role in the pathological and
physiological processes of early brain injury following subarachnoid hemorrhage …

PM2. 5 exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway

H Mei, D Wu, Z Yong, Y Cao, Y Chang, J Liang… - Science of The Total …, 2024 - Elsevier
In recent years, air pollution has garnered global attention due to its ability to traverse
borders and regions, thereby impacting areas far removed from the emission sources. While …