Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Idiopathic pulmonary fibrosis: Current and future treatment

DS Glass, D Grossfeld, HA Renna… - The clinical …, 2022 - Wiley Online Library
Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …

Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS/ERS/JRS/ALAT clinical practice guideline

G Raghu, M Remy-Jardin, L Richeldi… - American Journal of …, 2022 - atsjournals.org
Background: This American Thoracic Society, European Respiratory Society, Japanese
Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior …

Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Precise identification of cell states altered in disease using healthy single-cell references

E Dann, AM Cujba, AJ Oliver, KB Meyer… - Nature Genetics, 2023 - nature.com
Joint analysis of single-cell genomics data from diseased tissues and a healthy reference
can reveal altered cell states. We investigate whether integrated collections of data from …

ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling

J Liu, Z Wu, Y Liu, Z Zhan, L Yang, C Wang… - Journal of …, 2022 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with
pathophysiological characteristics of transforming growth factor-β (TGF-β), and reactive …

TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis

Z Ye, Y Hu - International journal of molecular …, 2021 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

Integrins as a drug target in liver fibrosis

SR Rahman, JA Roper, JI Grove, GP Aithal… - Liver …, 2022 - Wiley Online Library
As the worldwide prevalence of chronic liver diseases is high and continuing to increase,
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

F Zhang, EA Ayaub, B Wang… - EMBO molecular …, 2020 - embopress.org
Fibrotic diseases cause organ failure that lead to~ 45% of all deaths in the United States.
Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to …