Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Spatially resolved omics technologies reveal the spatial organization of cells in various
biological systems. Here we propose SLAT (Spatially-Linked Alignment Tool), a graph …

PAX 8 is a transcription factor that is essential for embryonic development of the kidney,
Müllerian organs, and thyroid. It may also have a role in tumor development in these organs …

Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

The mammalian pro-and mesonephros are transient embryonic kidneys essential for
urogenital system development. The nephric (Wolffian) duct, which is a central constituent of …

Signaling by GDNF through the Ret receptor is required for normal growth of the ureteric bud
during kidney development. However, the precise role of GDNF/Ret signaling in renal …

Embryonic stem (ES) cells have been induced to differentiate in vitro into a broad spectrum
of specialized cell types, including hematopoietic, pancreatic, and neuronal cell types. Such …

Pax genes are important regulators of kidney development. In the mouse, homozygous Pax2
inactivation results in renal agenesis, a phenotype that has largely precluded the analysis of …