This article reviews the effects of the short-chain fatty acid butyrate on histone deacetylase
(HDAC) activity. Sodium butyrate has multiple effects on cultured mammalian cells that …

Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …

Members of the HMGA (aka HMGI/Y) family of 'high mobility group'(HMG) proteins
participate in a wide variety of nuclear processes ranging from chromosome and chromatin …

The regulated production of several terminally differentiated cell types of the blood and
immune systems (haematopoiesis) has been the focus of many studies on cell-fate …

The interaction between 17β‐estradiol and estrogen receptor alpha (ER‐α) plays an
important role in breast carcinogenesis and breast cancer treatment. ER‐α is a critical …

Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

The circadian clock is regulated at the molecular level by feedback circuits of a group of
genes known as" clock genes", which establish a mechanism that controls circadian cellular …

Breast cancer encompasses a heterogeneous group of diseases at the molecular level. It is
known that chemosensitivity of breast cancer depends on its molecular subtype. We …

Regulation of gene expression involves the coordinated activities and interplay between
chromatin remodeling factors and transcription factor recruitment. Histone …

Sp1 and Sp3 are ubiquitously expressed mammalian transcription factors that function as
activators or repressors. Although both transcription factors share a common domain …